Our research in the scope of the natural products has been a powerful tool for combating several diseases like cancer and other pathological disorder, having contributed to get and to understand all the mechanism involved onto the formation of anticancer and anti-infective drugs as well as on Central Nervous System (CNS). Thus, "oxoisoaporphines" (7H-dibenzo[de,h]quinolin-7-one) are a small group of isoquinoline alkaloids that have shown an important chemical characteristic as antidepressive pro-drugs. In this sense, these alkaloids that bearing a nitrogen atom and a carbonyl group at C-1 and C-7 respectively, they have demostrated with several chemical structures, either total or partially hydrogenated, a high and selective ability to the inhibition of the isoform A of the human monoamine oxidase (h-MAO-A) in nanomolar range, according to the IC50 value. This unusual pharmacological property does not reported in the current bibliography due to that this type of pharmacological behaviour only had been found in certain amphetamine derivatives.

On the other hand, similar chemical structres called "perimidinones" (7H-benzo[e]perimidin-7-one) in the last decades, have been used as paintings. However, our research group has found that this alkaloid and its derivatives have an interesting reactivity in the photochemical activity on the production of singlet oxygen, a pioneer in the treatment of cancer with photodynamic therapy. Due to the excellent results in the scope of the pharmacology and using molecular docking in order to see the different chemical interactions between the alkaloid and receptor, these molecules could give us an alternative against depression and anxiety like oxoisoaporphine derivatives with low cytotoxicity and good bioavailabllity if these compounds were few soluble in aqueous solution. Thus, the next chemical structures of "oxoisoaporphines" and "perimidinones" are shown as follows: